China was the first country in the world to synthesize crystalline insulin, a bioactive protein. 中国在世界上最早用人工方法合成一种有生物活力的蛋白质--结晶胰岛素。
Results: Compared with positive and basic treated groups, the quantities of BG, glycosylation of serum albumin in serum, glucose, sorbitol and fructose in crystalline lens were decreased evidently, the levels of insulin in serum were increased distinctly in Tang-zhang-ming treated group. 结果:在降低糖尿病大鼠的血糖、糖化血清蛋白指数以及晶状体组织中葡萄糖、果糖和山梨醇含量以及提高血清胰岛素方面,糖障明中药治疗组均明显优于阴性对照组和基础治疗组。
The Proposing of the Total Synthesis of Crystalline Insulin Project 胰岛素人工合成课题的提出
Crystalline bovine insulin has been synthesized from the S-sulphonate derivatives of synthetic A-and natural B-chains of bovine insulin, and the A-chain derivative(ⅰ) has been prepared from synthetic peptide intermediates. 本文报导了牛胰岛素A链的S-磺酸盐(Ⅰ)的合成以及自Ⅰ和天然B链S-磺酸盐(Ⅱ)组合为结晶牛胰岛素的半合成。
Synthesis of A-chain of bovine insulin and partial synthesis of crystalline bovine insulin from synthetic a-and natural B-chains 牛胰岛素A链的合成及其与天然B链组合成结晶胰岛素
Methods: The animal model of diabetes was introduced by streptozotocin, and the glucose, sorbitol and fructose in crystalline lens and the blood glucose ( BG), glycosylation of serum albumin and insulin in serum were detected. 方法:以链脲佐菌素造成糖尿病动物模型,测定各实验组晶状体组织中葡萄糖、果糖、山梨醇含量以及血糖、糖化血清蛋白指数和血清胰岛素。
Artificial synthesis of crystalline insulin is considered to be The first recent touch on the Nobel Prize, meanwhile, it is a pity that The Nobel Prize brushed past Chinese Science. 结晶胰岛素的人工合成被认为是中国科学与诺贝尔奖最近的一次接触,同时与诺贝尔奖擦肩而过也成为中国科学的遗憾。